MSM has been reported to affect the compartmentalization and metabolism of sulfur. MSM may donate sulfur to keratin, which could help strengthen the bonds between keratin molecules in the hair and nails.
When administered orally, MSM is rapidly absorbed, well-distributed, and efficiently excreted from the body. It is well-tolerated by most individuals at dosages of up to 4 g daily, with few known and mild side effects. Therefore, a prospective clinical study was designed to examine the effect of oral administration of MSM on the condition of the hair and nails. In addition, this study sought to identify the best dose for optimum efficacy. The study was conducted at a third-party clinical testing facility International Research Services Inc.
The study was approved by the Allendale Institutional Review Board IRB , and informed consent was obtained from each participant prior to enrollment. A total of 63 subjects completed the study. They were healthy with no acute or chronic disease or medical condition, including dermatological problems, that could put them at risk in the opinion of the Principal Investigator or compromise study outcomes.
Subjects who regularly used nutritional supplementation within the previous 2 weeks were excluded. The subjects were not participating in any other clinical studies involving the face.
Pregnant and lactating women were excluded. The regular use of facial products and color-cosmetics for at least 2 weeks prior to study enrollment was allowed during the study period. In contrast, the use of other systemic or topical medications and treatments was prohibited during the study.
The panel was divided into 2 groups. The subjects were instructed to take the capsules in the morning with or without food for 4 months and to refrain from using any hair or nail treatment products and from receiving manicures for the course of the study. Expert visual grading of hair shine, volume, overall health and split ends was conducted at baseline and at weeks 4, 8, 12, and This grading scale was created and validated internally by IRSI and used a cm scale where 1 was none and 10 was extreme for each parameter.
At each time point, the subjects also assessed the same parameters via a questionnaire that asked the participants to indicate their level of agreement with a statement regarding the results on a 5-point scale. Nails were also visually graded by trained experts using a cm scale, where 1 was none and 10 was extreme for nail shine and overall appearance at baseline and at weeks 2, 4, and 8.
At each time point, the subjects also assessed the condition of their nails via a questionnaire. Visual assessments were analyzed with descriptive statistics; paired t-test monadic. Figure 1 shows the effects of oral administration of MSM on hair condition.
With respect to the visual grading of hair condition Fig. In the subject self-assessment of hair condition Fig. Only 1 of the subjects in Group A disagreed after 4 weeks and 16 weeks. Only 2 of the subjects in Group B disagreed after 4 weeks and 16 weeks.
While visual grading of split ends did not show a change with treatment, most subjects noticed some improvement with use Fig. In Group A, only 4 subjects disagreed after 4 weeks and 1 disagreed after 16 weeks. In Group B, 4 subjects disagreed after 4 weeks and 2 disagreed after 16 weeks.
Most subjects agreed that the product improved their hair volume Fig. As shown in Fig. As with the other parameters, most of the subjects agreed that treatment resulted in an overall healthier appearance Fig. Figure 1. Figure 2 shows assessments of nail condition after treatment with MSM. As observed in Fig. While the higher dose was more effective than the lower dose, nail shine continued to improve over the course of the study for both concentrations.
Most of the subjects agreed that nail shine improved with treatment Fig. Furthermore, most subjects agreed that their nails appeared to be healthier Fig. Figure 2. A-I, B-I: Nail improvement as assessed by expert visual grading. Although myriad instruments are available to measure the condition of hair and nails, the ultimate satisfaction of the consumer depends on palpable changes as perceived through visual observation and subject self-perception.
In this study, participant self-assessment questionnaires indicated overall satisfaction with hair and nail health. Consistent with previous findings for the skin, 27 MSM improved the condition of the hair and nails in a dose-related manner.
Measurable improvements with 2 assessment tools suggest that MSM supplementation is beneficial for hair and nail health in this study demographic. The most noticeable effects were the improvements in hair shine and volume and nail shine.
Similarly, the subjects themselves reported predominantly positive responses. MSM is a popular dietary supplement that is used for various reasons, including the maintenance of normal keratin levels in the hair, skin, and nails. Extensive disulfide bonding contributes to the insolubility of keratins and thermally stable crosslinking that imparts significant strength and rigidity to hair and nail structures.
The amount of cysteine disulfide keratin determines the strength of the bonds to make hard cells like nails, or softer to make flexible tissue like hair and skin. The more flexible and elastic keratin of human hair has fewer interchain disulfide bridges than that in mammalian fingernails.
Supplementation with MSM can provide a good source of sulfur to strengthen these bonds. Nails can be a barometer of overall health and aging. By reducing inflammation, MSM may soothe the scalp and support healthy hair. MSM is essentially organic sulfur.
Sulfur is also one of the most abundant components of keratin, the protein that makes up hair, nails, and epidermal tissue. MSM is a natural source of sulfur, and it is readily absorbed. This may encourage the formation of keratin and contribute to stronger hair. In a mouse study, researchers evaluated the effects of topical MSM for hair growth used in conjunction with magnesium ascorbyl phosphate.
Researchers tested aqueous solutions of magnesium ascorbyl phosphate 7. These solutions were applied to the shaved backs of male mice once per day for a total of 20 days. Results were based on visual scoring on a hair growth quantification scale, transdermal penetration, and intradermal retention studies performed in vitro. Promotion of hair growth was found to be dependent on the MSM dosage in relation to the magnesium ascorbyl phosphate solution.
Results also suggest that the presence of MSM increased the transdermal retention of the magnesium ascorbyl phosphate. This shows evidence that topical application of MSM and magnesium ascorbyl phosphate may help to promote hair growth and prevent hair loss.
In another study, researchers evaluated the effects of a nutraceutical containing mg of MSM, mg of hyaluronic acid, and mg of L-carnosine on two groups of women affected by facial skin photoaging.
Participants took a daily dose of the nutraceutical or a placebo. Although the study mostly examined effects on facial tissue the treatment group showed significant improvements in facial skin hydration and elasticity , the nutraceutical was also found to positively affect non-skin tissues, including hair.
The subjects who had taken the nutraceutical reported notable improvements in their hair, including both appearance and texture, compared to the placebo group. However, the study was unable to confirm if this was caused by MSM or a combination of all three compounds in the oral supplement. As MSM supplementation is still undergoing research for its effects on hair growth, there are no official guidelines for recommended dosage. However, MSM is generally recognized as safe and is well-tolerated by most people at serving sizes of up to 4 grams orally per day.
Keep in mind there's little scientific evidence of its health benefits. If you want to give it a try, take an oral or topical supplement daily. Aside from supplements, you can eat more foods that contain MSM and other beneficial sulfuric compounds, such as fish, kale, and onions.
As with any dietary supplement, consult your doctor before taking MSM, and ask them to recommend a dosage. To take MSM safely, take 3 doses a day with water or a meal to prevent an upset stomach. The recommended dosage is 6 grams per day, so each dose should be no more than 2 grams. People report that MSM takes about 2 weeks to have a visible impact on your hair growth. MSM is also found in protein-rich foods like eggs, fish, and legumes, so try to include these items in your diet.
Other food options include adding raw onions and garlic to salads, and eating more kale and cabbage. If you experience any side effects, like diarrhea, sore head, or stomach pain, reduce your MSM dosage or stop taking it altogether. Did this summary help you? Yes No. Log in Social login does not work in incognito and private browsers. Please log in with your username or email to continue. No account yet? Create an account. Edit this Article. We use cookies to make wikiHow great. By using our site, you agree to our cookie policy.
Cookie Settings. Learn why people trust wikiHow. Method 1. Take up to 6 grams per day of MSM in tablet form. While the recommended daily dosage is up to 6 grams, divided into 3 doses, start at a lower dose and see how it affects you. Try taking a 1-gram tablet 3 times a day, and increase your dosage over the course of 1 to 2 weeks.
To prevent an upset stomach, take each dose with a glass of water and a meal. It's most often used for arthritis and muscle pain, so check your store's joint health section. Those who use MSM and report positive results say that it takes at least 2 weeks to notice effects. Mix powdered MSM with water if you don't like taking pills.
Go with the oral dosage form that you're most comfortable taking regularly. If you can't or don't want to swallow pills 3 times a day, use the powdered form.
0コメント