See all related overviews in Oxford Reference ». A theory to explain the partial degeneracy of the genetic code due to the fact that some t-RNA molecules can recognize more than one codon. The theory proposes that the first two bases in the codon and anticodon will form complementary pairs in the normal antiparallel fashion. From: wobble hypothesis in A Dictionary of Zoology ».
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Search for: 'wobble hypothesis' in Oxford Reference ». All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single entry from a reference work in OR for personal use for details see Privacy Policy and Legal Notice. Oxford Reference. Publications Pages Publications Pages. Recently viewed 0 Save Search. I is the nucleoside Inosine that is formed in tRNA by the removal of an amino group from adenosine.
The 16S RNA in the 30S ribosomal subunit possesses a means of examining whether the standard Watson-Crick base pairs have formed between the 1st codon base and the 3rd anticodon base, as well as between the 2nd codon base and the 2nd anticodon base.
However, there is no system to check whether the 3rd codon base and the 1st anticodon base are complimentary to one another and this amounts to the more lenient base-pairing that is witnessed exclusively at the 3rd position [7]. The Wobble Hypothesis explains why multiple codons can code for a single amino acid.
One tRNA molecule with one amino acid attached can recognise and bind to more than one codon, due to the less-precise base pairs that can arise between the 3rd base of the codon and the base at the 1st position on the anticodon.
This hence explains why more codons exist than there are specific tRNA molecules [8]. The Wobble Hypothesis also illustrates why the only variability between many codons, that encode the same amino acid, is their 3rd base [9].
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