Participants experienced equal pain relief 30 and 60 minutes after the medication was taken. However, those who were given hydrocodone experienced constipation more frequently than participants who used oxycodone. Another study found that the combination of oxycodone and acetaminophen was 1. Both oxycodone and hydrocodone are sold as brand-name drugs and as generic alternatives. Generic medications are cheaper than their brand-name counterparts. For that reason, you may wish to try the generic versions.
Before you do that, consult your doctor. Some generic versions of medications have different ratios of active and inactive ingredients. To be classified as generic by the U. Food and Drug Administration, the drug must include the same strength of active ingredients, but may not have the same amount of inactive ingredients. If you need to use the brand name but find that the price tag is too high, prescription drug insurance and prescription coupons may help reduce your total cost.
The most common side effects of oxycodone and hydrocodone are similar. These side effects include:. Oxycodone is more likely to cause side effects of dizziness and drowsiness, as well as fatigue, headaches, and feelings of euphoria. Hydrocodone is more likely to cause constipation and stomach pain. People who have asthma or breathing difficulties may need to avoid these pain medications entirely. Also, because of the risk of increased constipation, people who have blockages or difficulty with constipation may not want to take oxycodone or hydrocodone.
These drugs can make these conditions worse. The combination of alcohol and painkillers can cause extreme dizziness or drowsiness. The combination can also damage your liver. A study published in the American Journal of Obstetrics and Gynecology found that there was an association between opioid treatment and certain birth defects.
Also, some of the side effects of the medication could cause problems for you while you are pregnant. These side effects include behavior changes, difficulty breathing, constipation, and lightheadedness. They can pass through breast milk and harm your baby. Even at low levels and when taken exactly as prescribed, these medications can be habit-forming.
Misuse of these narcotics can lead to addiction, poisoning, overdose, or even death. Both hydrocodone and oxycodone are effective at easing acute and chronic pain. They both cause very similar side effects. The differences between the two drugs are minimal, so the best way to pick which drug is right for you is by having a conversation with your doctor. Based on your personal medical history, your doctor can weigh the pros and cons of the two medications. Some researchers and medical professionals find that hydrocodone is less powerful compared to oxycodone.
In that case, your doctor may prefer to start you on a smaller dose to see how your body handles the medication. The list of opioids is long. Learn their forms, factors used in choosing them, and tips for taking them safely.
However, to the best of the authors' knowledge, no previous reports have compared the efficacies of these commonly prescribed agents. Objectives: To compare the efficacies of oxycodone and hydrocodone for the treatment of acute pain associated with fractures in emergency department ED patients.
Methods: This prospective, double-blind, randomized, controlled trial was conducted at an urban trauma center with an annual census of 65, Eligible participants included ED patients over the age of 12 years with fractures who consented to participate. Subjects were randomized to receive either oxycodone 5 mg orally [po] with acetaminophen, or hydrocodone 5 mg po with acetaminophen. Both drugs are available in extended-release forms, which are suitable for people who have taken opioids for at least a week and have pain that requires treatment on an ongoing basis.
Opioids can interact with other drugs, and they are also highly addictive. As such, they are not suitable for everyone. People should avoid taking them if they have a history of substance abuse or are taking medications that may interact with opioid medications. Oxycodone and hydrocodone both belong to a class of medications called opioid analgesics. These medications work by affecting how the brain and central nervous system process pain signals. Opioid analgesics are Schedule II drugs, which means that they are medically useful but have a high potential for abuse.
As such, they are available strictly via prescription only. A person typically takes extended-release oxycodone every 12 hours with food, whereas they will usually take extended-release hydrocodone once daily , at about the same time each day. A person should not crush, chop, soak, or otherwise tamper with extended-release tablets before taking them. These medications are highly addictive, and stopping them suddenly could lead to symptoms of withdrawal. Many people believe oxycodone to be a better pain reliever than hydrocodone.
A study set out to compare the effectiveness of an oxycodone and acetaminophen drug combination with that of a hydrocodone and acetaminophen drug combination. The study found no significant differences between the two drug combinations with regard to treating acute musculoskeletal pain.
Both oxycodone and hydrocodone are effective in reducing pain sensations. However, they will not address the underlying cause of the pain. Due to the risks of dependence and addiction, many experts recommend exploring other pain options before taking opioids. Some possible side effects of these medications include :. Research has shown that oxycodone-acetaminophen combinations are more likely than hydrocodone-acetaminophen combinations to induce nausea and dizziness. People who take any opioid medication for a significant amount of time may experience drug tolerance.
This effect means that a person needs to take increasing amounts of a medication for it to achieve the same effect. Tolerance increases the risk of substance abuse. People who stop taking an opioid drug may experience withdrawal, especially if they have been taking high doses of the drug or have been taking it for an extended period.
Withdrawal occurs because the body is learning to adjust to the absence of opioids in its system. Some potential symptoms of opioid withdrawal include:. Hydrocodone and oxycodone can interact with many different drugs, including some medications belonging to the following groups:. Opioid medications also interact with alcohol and some recreational drugs, as well as certain supplements. To avoid the risk of drug interactions, a person should provide their doctor with detailed information about all of the prescription medications and over-the-counter OTC supplements that they are taking.
They should also refrain from drinking alcohol or using recreational drugs while taking either oxycodone or hydrocodone. Both oxycodone and hydrocodone can lead to dependency and addiction , especially if a person takes either drug at a high dose or for an extended period.
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