What kind of gene is height

Nature 33 , — Weedon, M. Lettre, G. Gudbjartsson, D. Gunnell, D. Visscher, P. The International HapMap Consortium. Nature , — Sanna, S. Easton, D.

Rebbeck, T. Wray, N. Genome Res. Purcell, S. Bioinformatics 19 , — Download references. Peter M. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Sizing up human height variation.

Around a quarter of white Europeans will carry two versions of the "tall" version of the gene, with another quarter carrying two "short" versions. Scientists at Harvard University and Children's Hospital Boston joined British researchers at Oxford University and the Peninsula Medical School in Exeter to scour the genomes of 5, white European patients who had volunteered DNA samples and details of their height and weight for medical studies into diabetes and heart disease.

The scientists identified the HMGA2 gene as playing a major role in height variation and noted that changing just one letter in the genetic code had a significant effect on growth. The discovery was confirmed by searching for the same two versions of the gene in a further 30, patients. A study published in suggests that HMGA2 is fundamental to human growth and may play a role in tumour formation.

Transactions of the Royal Society of Edinburgh 52, — Silventoinen, K. Determinants of variation in adult body height. Perola, M. Combined genome scans for body stature in 6, European twins: evidence for common Caucasian loci. PLoS Genet. Cho, Y. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

Hao, Y. Genome-wide association study in Han Chinese identifies three novel loci for human height. Lango Allen, H. Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Nature , — Identification, replication and fine-mapping of Loci associated with adult height in individuals of african ancestry. Wood, A. Defining the role of common variation in the genomic and biological architecture of adult human height. Bozzoli, C. Adult height and childhood disease. Demography 46, — Steckel, R. Heights and human welfare: Recent developments and new directions.

Explorations in Economic History 46, 1—23 Eveleth, P. Worldwide variation in human growth Cambridge University Press, Cambridge, Bogin, B. The growth of humanity Wiley-Liss, New York, Dubois, L. Genetic and environmental contributions to weight, height and BMI from birth to 19 years of age: an international study of over 12, twin pairs. PLoS One 7, e Mook-Kanamori, D.

Heritability estimates of body size in fetal life and early childhood. Genetic regulation of growth from birth to 18 years of age: the Swedish young male twins study. Genetic regulation of growth in height and weight from 3 to 12 years of age: a longitudinal study of Dutch twin children. Twin Res. Hur, Y. Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins.

Lond 32, — Jelenkovic, A. Genetic and environmental influences on growth from late childhood to adulthood: a longitudinal study of two Finnish twin cohorts. Heritability of adult body height: a comparative study of twin cohorts in eight countries. Genetic and environmental influences on body size in early childhood: a twin birth-cohort study. Estourgie-van Burk, G. Body size in five-year-old twins: heritability and comparison to singleton standards. Sex differences in genetic and environmental factors contributing to body-height.

Phillips, D. Twin studies in medical research: can they tell us whether diseases are genetically determined? Lancet , — Cole, T. The secular trend in human physical growth: a biological view. Polderman, T. Meta-analysis of the heritability of human traits based on fifty years of twin studies.

Yang, J. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. A novel common variant in DCST2 is associated with length in early life and height in adulthood. Aksglaede, L. Forty years trends in timing of pubertal growth spurt in , Danish school children. PLoS One 3, e Hermanussen, M. Studying human growth and development ed Hermanussen, M. Schweizerbart Science Publishers, Stuttgart, Wehkalampi, K.

Genetic and environmental influences on pubertal timing assessed by height growth. Bulik-Sullivan, B. An atlas of genetic correlations across human diseases and traits. Cousminer, D. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Rao, E. Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome.

Ratcliffe, S. Growth during puberty in the XYY boy. Gudbjartsson, D. Many sequence variants affecting diversity of adult human height.

Robinson, M. Population genetic differentiation of height and body mass index across Europe. Fujiwara, S. Differences in health characteristics between native Japanese and Japanese-Americans. Cross Cult. Liu, Q. Zietsch, B. Variation in human mate choice: simultaneously investigating heritability, parental influence, sexual imprinting and assortative mating.

Joshi, P. Directional dominance on stature and cognition in diverse human populations. Neale, M. Methodology for genetic studies of twins and families Kluwer Academic Publishers, Dordrecht, Boker, S. Psychometrika 76, — Purcell, S.

Variance components models for gene-environment interaction in twin analysis. Download references. Wave 5 was supported by funding to Alice M. Gregory from Goldsmiths, University of London. Anthropometric measurements of the Hungarian twins were supported by Medexpert Ltd. Buchwald, PI. Jacob v. Patrik K. Magnusson, Nancy L. Maria A. Wendy Cozen, Amie E. Jane Wardle, Clare H. Tom A. McAdams, Thalia C. Robert F. Margaret Gatz, Laura A. Meike Bartels, Toos C.

You can also search for this author in PubMed Google Scholar. All authors have commented the manuscript and read and approved the final version of the manuscript.

This work is licensed under a Creative Commons Attribution 4. Reprints and Permissions.